The site is secure. In July, 2013, FDA took this action in response to a food additive petition filed by Congressman Edward Markey [10] of Massachusetts. With more than half of the global demand, the Asian market will . Bisphenol A (BPA) is a chemical building block that is used primarily to make polycarbonate plastics. [66][67][68] The primary source of human exposure is via food, as epoxy and PVC are used to line the inside of food cans to prevent corrosion of the metal by acidic foodstuffs. In particular, infants are considered to be at greater risk,[83] leading to bans on the use of BPA in baby bottles and related products by the US,[84] Canada,[85] and EU[86] amongst others. fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. This process, also known as a one-step process, is commonly used for the preparation of low and medium molecular weight bisphenol A epoxy resins. :30583-72-3 Molecular formula:C18H33ClO3 Molecular weight: 332.91 Appearance:Colorless liquid Assay 60% Hydrogenated Bisphenol A Epoxy Resin Specification: Hydrogenated Bisphenol A Epoxy Resin Application Bisphenol A- (epichlorhydrin)epoxy resin, polymer with polyethylene glycol, castor oil and triethylenetetramine IUPAC names 1 Print infocard Substance identity Substance identity The 'Substance identity' section is calculated from substance identification information from all ECHA databases. [35][34], BPA has a fairly high melting point but can be easily dissolved in a broad range of organic solvents including toluene, ethanol and ethyl acetate. Bisphenol A can leach into food from the protective internal epoxy resin coatings of canned foods and from consumer products such as polycarbonate tableware, food storage containers, water bottles, and baby bottles. For example, FDA has participated with Health Canada in encouraging industry efforts to refine their manufacturing methods for the production of infant formula can linings to minimize migration of BPA into the formula. Bisphenol A diglycidyl ether (DGEBA) can be called a small-molecule adhesive. The results of this study showed no effects of BPA at any dose in the low-dose range. bisphenol A (BPA), a colourless crystalline solid belonging to the family of organic compounds; its molecular formula is C 15 H 16 O 2. Recently, FDA granted two petitions requesting that FDA amend its food additive regulations to no longer provide for the use of certain BPA-based materials in baby bottles, sippy cups, and infant formula packaging because these uses have been abandoned. Polyols can be compounds such as 1,4-butanediol. MAIN APPLICATIONS Bisphenol A Epoxy is widely used in the manufacture of: Epoxy resins; Phenolic resins . BPS differentiates from BPA by possessing a sulfone group (SO 2) as the central linker of the . Lactational transfer of bisphenol A in Sprague-Dawley rats. Over the following decade, coatings and resins derived from similar materials were described by workers at the companies of DeTrey Freres in Switzerland and DeVoe and Raynolds in the US. The performance of specialized collections of bisphenol A epoxy resin system components in the evaluation of workers in an occupational health . Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. [28] BPA was never used as a drug. 250/ Ton Get Latest Price. Make any industrial chemical reactions run smoothly with the organic intermediate compounds available at Alibaba.com's chemical store. The site is secure. FDA has amended its regulations to no longer provide for the use of BPA-based polycarbonate resins in baby bottles and sippy cups. [106][107] BPA appears able to effect development and reproduction in a wide range of wildlife,[107] with certain species being particularly sensitive, such as invertebrates and amphibians.[106]. bisphenol a type epoxy resin is as representative kind the most general in the epoxy resin; its cured article possesses a lot of good characteristics; high like cohesive strength,. It may also be used as an ingredient in some resins, which can act as a lining on the inside of some metal food and drink cans. The results of the CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirm BPAs safety. Empirical Formula (Hill Notation): C21H24O4 CAS Number: 1675-54-3 Molecular Weight: 340.41 Beilstein: 299026 EC Number: 216-823-5 MDL number: MFCD00080480 PubChem Substance ID: 57654090 NACRES: NA.77 Pricing and availability is not currently available. . BPA is a structural component in polycarbonate beverage bottles. Epoxy resin is based on epichlorhydrin and bisphenol A. Due to interest in the exposure to bisphenol A in the community1 and the workplace, OSHA developed a validated method to collect and analyze bisphenol A and diglycidyl ether of bisphenol A. The .gov means its official. NIEHS is committed to conducting the most rigorous research in environmental health sciences, and to communicating the results of this research to the public. [2]FDA Science Board Subcommittee on Bisphenol A. Use a solvent mixture of petroleum ether and ethyl acetate (volume ratio 3:1) a developing solvent to purify it by column chromatography according to the above procedure to obtain DGEBA. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. Table 1, Table 2 present the . Polycarbonate is strong and durable, but over time it may break down from over use at high temperatures. [36] It may be purified by recrystallisation from acetic acid with water. Polycarbonate drinks containers are also a source of exposure, although most disposable drinks bottles are actually made of PET, which contains no BPA. 2005 2022 American Chemistry Council, Inc. Many BPA-containing materials are non-obvious but commonly encountered,[17] and include coatings for the inside of food cans,[18] clothing designs,[19] shop receipts,[20] and dental fillings. [26] The utilization of BPA further expanded with discoveries at Bayer and General Electric on polycarbonate plastics. In recent years, many claims have been made about the health effects of BPA. It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. Comparatively minor amounts of BPA are also used as additives or modifiers in some commodity plastics. After their first commercial production in the late 1940s, epoxy resins comprise a wide family of materials today. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. At 830C). This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. #12-03 Keck Seng Tower, [90] Different expression of ERR- in different parts of the body may account for variations in bisphenolA effects. While they have high mechanical strength values similar to epoxy resins, they are easy to apply similar to unsaturated polyester resins. To improve the compatibility between flame retardant and epoxy resin (EP) matrix, amino phenyl copper phosphate-9, 10-dihydro-9-oxygen-10-phospha-phenanthrene-10-oxide (CuPPA-DOPO) is synthesized through surface grafting, which is blended with EP matrix to prepare EP/CuPPA-DOPO composites. [2] Also in 2008, the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, part of the National Institutes of Health, released the Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.[3]. Furthermore, composite . Chemical compound used in plastics manufacturing, InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, Except where otherwise noted, data are given for materials in their, "Chemical Fact Sheet Cas #80057 CASRN 80-05-7", Ullmann's Encyclopedia of Industrial Chemistry, "Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A", "Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A", "The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands", "Bisphenols, Benzophenones, and Bisphenol A Diglycidyl Ethers in Textiles and Infant Clothing", "Pit and fissure sealants for preventing dental decay in permanent teeth", "Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review", " i ", "Condensationsproducte aus Ketonen und Phenolen", "The politics of plastics: the making and unmaking of bisphenol a "safety", "Synthetic strogenic Agents without the Phenanthrene Nucleus", "Molecular Structure in Relation to Oestrogenic Activity. [4] The studies were evaluated for their relevance for regulatory hazard and/or risk assessment. Because of the way BPA is processed in the body, it is very unlikely that exposure to BPA at typical levels could cause health effects. There is no scientific basis to say that BPA-free products are safer than products with BPA. Properties of copolymer epoxy resins. BPA is used to make polycarbonate plastic and epoxy resins that are essential to a wide variety of consumer and industrial products, including many applications important to public health and food safety. Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications, 31 October 2008. Industrially, a large excess of phenol is used to ensure full condensation; the product mixture of the cumene process (acetone and phenol) may also be used as starting material. This search feature obtains best-matches with the terms you choose, and shows an overall score based on the scientific rankings. The safety of a food additive is not relevant to FDAs determination regarding whether a certain use of that food additive has been abandoned. Toxicol Lett. [105] As such, the precise effects of BPA on the growth, reproduction, and development of aquatic organism is not fully understood. PBE can be used as a reinforcing polymer on nanotubes and nanoparticles which can be useful in electronics, optical and aerospace based applications. While air, dust, and water are other possible sources of exposure, BPA in food and beverages accounts for the majority of daily human exposure. Epoxy is a synthetic resin that uses two chemical components (typically diglycidyl ethers and a combination of bisphenol A and epichlorohydrin) to harden or cure. 2013 Feb 15;267(1):41-8. m) Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. Some, but not all, plastics that are marked with recycle codes 3 or 7 may be made with BPA. Supplier. 2011 Dec 15;207(3):298-305. f) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Its chemical formula is (CH3)2C (C6H4OH)2. Because of its extreme durability and strength, polycarbonate plastic is particularly useful for making component parts that need to be thin and light, but strong. [11] www.who.int/foodsafety/areas_work/chemical-risks/bisphenol/en/, An official website of the United States government, : [96] The solubility of BPA in water is low (~300g/ton of water)[2] but this is still sufficient to make it a significant means of distribution into the environment. Bisphenol A (BPA) is a diphenylmethane derivative, commonly used in the production of polycarbonate plastics, epoxy resins, and various other plastic-based consumer products. [22] The European Chemicals Agency has added BPA to the Candidate List of substances of very high concern (SVHC), which would make it easier to restrict or ban its use in future. EC number: 500-130-2 But, lets first start by understanding thermosets. Polycarbonate plastic is used to make hard plastic items, such as baby bottles, re-useable water bottles, food containers, pitchers, tableware and other storage containers. [28][29][30] Subsequent work found that it bound to estrogen receptors tens of thousands of times more weakly than estradiol, the major natural female sex hormone. Other Details: - Bisphenol resin is extensively used with consumer products such as applying coatings inside of food and beverage cans as this leave no bad effects or any risk of hazard to human health. BPA Initiatives - The National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consortium-based approach to optimize BPA-focused research investments to more effectively address data gaps and inform decision making. Global production in 2022 is expected to reach 10 million tonnes. Health care providers depend on medical devices and equipment made with BPA for a transparent view within the human body so they can check for the presence of air bubbles or other obstructions during medical procedures. Find here online price details of companies selling Bisphenol Resin. . Using the data and design from the rodent subchronic study, the National Toxicology Program/Food and Drug Administration (NTP/FDA) is conducting a long-term toxicity study of BPA in rodents to assess a variety of endpoints, including novel endpoints where questions have been raised. The chemical formula of Bisphenol A is C15H16O2. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. Toxicol Appl Pharmacol. [65][24], As a result of the presence of BPA in plastics and other commonplace materials, most people are frequently exposed to trace levels of BPA. Epub 2014 Feb 4. b) Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. Get info of suppliers, manufacturers, exporters, traders of Bisphenol Resin for buying in India. Bisphenol A was first synthesized by A.P. [90] It can also protect it from deactivation from the SERM 4-hydroxytamoxifen (afimoxifene). [ 4 ] the studies were evaluated for their relevance for regulatory hazard and/or assessment... 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